Locked-in syndrome is a condition in which a patient is aware and awake, but cannot move or communicate due to complete paralysis of nearly all voluntary muscles in the body except for the eyes. It is the result of a brain stem lesion in which the ventral part of the pons is damaged. The condition has been described as "the closest thing to being buried alive". In French, the common term is "maladie de l'emmuré vivant", literally translated as walled-in alive disease; in German it is sometimes called "Eingeschlossensein".[1]
Locked-in syndrome is also known as cerebromedullospinal disconnection,[2] de-efferented state, pseudocoma,[3] and ventral pontine syndrome.
The term for this disorder was coined by Plum and Posner in 1966
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